Close Menu

    Subscribe to Updates

    Get the latest creative news from FooBar about art, design and business.

    What's Hot

    COVID Antiviral Pills: What Scientists Still Want to Know

    October 9, 2021

    Does CBD Live Up to Its Claims of Health Benefits?

    October 9, 2021

    Ministers Could be Forced to Make NHS Workforce Plans Public

    October 8, 2021
    Facebook X (Twitter) Instagram
    Men's Health SecretsMen's Health Secrets
    • Demos
    • Health
    • Covid19
    • Buy Now
    Facebook X (Twitter) Instagram
    SUBSCRIBE
    • Home
    • Features
      • Example Post
      • Typography
      • Contact
      • View All On Demos
    • Sexual Health

      Androstenedione (Steroids) & Sex Drive

      July 31, 2016

      Did Medication Cause Erection Problems?

      May 20, 2016

      Correcting Diabetes-Related Erection Problems

      May 17, 2016

      Does Quitting Smoking affect Erections?

      May 14, 2016

      Diet, Lifestyle & Impotence

      May 11, 2016
    • Typography
    • News
      1. Health
      2. Covid19
      3. Fitness
      4. View All

      Does CBD Live Up to Its Claims of Health Benefits?

      October 9, 2021

      Student Gives Prosthesis Project a Lightning-Themed Touch

      October 7, 2021

      Hospital Fined for Allowing Medical Student to Suture Patient

      October 6, 2021

      4 Factors To Consider When Buying Your Next Toothbrush

      May 16, 2021

      COVID Antiviral Pills: What Scientists Still Want to Know

      October 9, 2021

      Opioid Drugs: A List of Common Prescription & Street Drugs

      May 14, 2021

      Minimal Access Surgery Training Institute Highlights

      May 12, 2021

      Covid Pregnancies: Symptoms, Risks, and Delivery

      April 14, 2021

      Hospitalizations Rising Among Fully Vaccinated in US, Study Finds

      September 9, 2021

      Law to Stop Surprise Medical Bills Faces Pushback from Doctors

      September 9, 2021

      Why Health Care Systems Should Invest in Medical Malls

      September 9, 2021

      What’s Really Happening in Herbal Medicines Market

      September 9, 2021

      Ministers Could be Forced to Make NHS Workforce Plans Public

      October 8, 2021

      FDA Authorizes Marketing of VR System for Chronic Pain Relief

      October 7, 2021

      Corona vs. Flu: Here’s How to Tell the Major Difference

      March 15, 2021

      5 Superfoods – Your Winter Diet for a Perfect Glowing Skin

      March 14, 2021
    • Buy Now
    Men's Health SecretsMen's Health Secrets
    Home » Guillain-Barré Syndrome
    Diseases

    Guillain-Barré Syndrome

    fitness-expertBy fitness-expertJuly 31, 2004No Comments5 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr Reddit WhatsApp Email
    Share
    Facebook Twitter LinkedIn Pinterest WhatsApp Email

    Guillain-Barré syndrome (GBS), is an acquired immune-mediated inflammatory disorder of the peripheral nervous system (i.e. not the brain or spinal cord). It is also called acute inflammatory demyelinating polyneuropathy, acute idiopathic polyradiculoneuritis, acute idiopathic polyneuritis, French Polio and Landry’s ascending paralysis.

    Overview
    The pathologic hallmark of the disease is loss of myelin in peripheral nerves due to an acute and progressive inflammation of unknown cause. It is suggested that it is an autoimmune disease, in which the sufferer’s immune system is triggered into damaging the nerve covering. There is some support for this in that half of all cases occur soon after a microbial infection or respiratory or gastrointestinal viral infection. Many cases developed in people who received the 1976 swine flu vaccine.

    Peripheral nerves originate in the spinal cord and proceed to their target tissues (mainly muscle, skin and all internal organs). Their most proximal parts emerging from the spinal cord are called nerve roots and the inflammation in most (but not all) typical Guillain-Barré syndrome cases starts in these roots. Therefore, this condition is also referred to as acute polyradiculoneuritis.

    Recent studies on the disease have demonstrated that approximately 80% of the patients have myelin loss, whereas, in the remaining 20%, the pathologic hallmark of the disease is indeed axon loss. The cases indicating the demyelinating form (AIDP) are called “acute motor and sensory axonal neuropathy” (AMSAN); the cases showing only motor symptoms (diffuse weakness) are called “acute motor axonal neuropathy” (AMAN). In a different and infrequent variant called Miller Fisher syndrome, patients develop ataxia, loss of tendon reflexes, and difficulty moving eye muscles but not weakness or sensory loss. All variants of Guillain-Barré syndrome are now supposed to be an autoimmune disease caused by antibodies against a variety of gangliosides found in abundant amounts in the peripheral nerve tissue.

    Prevalence
    GBS is a rare disease affecting about 1 to 2 people in every 100,000 annually. It does not discriminate with regard to the age or sex of sufferers. When diagnosed in young teenagers, it generally does not recurr for many years, although when it does, it often does so in the fourth or fifth decade of life, long after the patients may have forgotten the details of the original episode.

    Cause
    About one half of patients have a history of preceding viral infection within two to four weeks prior to exhibiting the onset of Guillain-Barré syndrome. Guillain-Barré syndrome may also be associated with immunizations, recent surgery or trauma, pregnancy, Hodgkin’s disease, chemo-therapy, and connective tissue diseases. The most frequently associated viral agents are cytomegalovirus (CMV), HIV, measles and herpes simplex virus. A bacterium called Campylobacter jejuni has recently been shown to be closely related with certain subtypes of the disease.
    Signs and symptoms

    Extensive damage of myelin causes disturbances in peripheral nerve functions, which can be classified as motor (affecting the muscle), sensory (affecting the skin) or autonomic (affecting the internal organs). Therefore, patients usually show two or more of the following symptoms: weakness (often symmetrical, in ascending fashion, leading to respiratory failure in one-third of cases), decreased sensation (numbness, loss of position sense), severe fluctuations in blood pressure, irregularities of heart rate, constipation and incontinence. Additional symptoms may be blurred vision, difficulty moving facial muscles, difficulty swallowing, and drooling.

    The symptoms are ascending weakness with abnormal sensations and then paralysis of the legs, arms, face and possibly breathing muscles. Miller-Fisher Syndrome, however, is a descending weakness, proceeding in the reverse order of the more common form of Guillain-Barré syndrome. Guillain-Barré syndrome is rarely fatal but there is no direct cure and recovery may need care in an intensive care unit and can take years (although people can recover in a few weeks as well).

    Diagnosis
    The diagnosis is established by electromyography examination, nerve conduction studies (NCS), and cerebrospinal fluid (CSF) examination. Electromyography and NCS show slowing of conduction velocities, indicating myelin loss; CSF examination reveals high protein content with usually normal or slightly elevated cell count, indicating severe nerve damage. These findings are usually prominent after the first week of the disease, so the clinical symptoms and findings are more valuable in the early stages.

    Treatment
    Supportive care with monitoring of all vital functions is the cornerstone of successful management. Because the immune mechanisms play a role in pathogenesis, plasma exchange or intravenous immunoglobulins over a course of treatment lasting five days may improve the outcome, preventing the need for a ventilator to be used. The use of intravenous immunoglobulins is not without risk, occasionally causing hepatitis, or in rare cases, renal failure if used for longer than five days. Although the corticosteroids may be used in treatment, they are no longer considered the drug of first choice in modern practice because they may occasionally worsen symptoms.

    Prognosis
    Approximately 80% of patients have a complete recovery and about 5-10% recover with severe disability. However, this is a grave disease and despite all improvements in treatment and supportive care, the death rate among patients with this disease is still about 2-3% even in the best intensive care units. Worldwide, the death rate runs slightly higher (4%), mostly from a lack of availability of life support equipment during the lengthy plateau lasting 4 to 6 weeks when a ventilator is needed in the worse cases.

    History
    The disease was first described by the French physician Jean Landry in 1859. In 1916, Georges Guillain, Jean Alexandre Barré and Andre Strohl discovered the key diagnostic abnormality of increased spinal fluid protein production, but normal cell count.

    Best Steroid Products Sales

    HGH GenShi

    Order HGH GenShi from Legal Supplier
    Substance: Human Growth Hormone 191 aa
    Manufacturer: Gen-Shi Laboratories
    Unit: 10 IU/vial

    Testosterona P

    Best Testosterona P from Legal Supplier
    Substance: Testosterone Propionate
    Manufacturer: Balkan Pharmaceuticals
    Unit: 5 x 1 mL amp (200 mg/mL)

    Genotropin 36iu (12mg)

    Best Genotropin 36iu (12mg)
    Substance: Human Growth Hormone
    Manufacturer: Pfizer
    Unit: vial (36 IU / 1 mL)

    fitness-expert

    Related Posts

    Hepatitis, Cirrhosis & Erection Problems

    April 6, 2016

    Peyronie’s Disease Causes Pain, Psychological Trauma

    February 24, 2016

    Understanding Hepatitis B

    September 13, 2015
    Leave A Reply Cancel Reply

    Don't Miss
    Covid19

    COVID Antiviral Pills: What Scientists Still Want to Know

    By troy-browningOctober 9, 20210

    To understand the new smart monitors and other pro devices of tech health, we should…

    Does CBD Live Up to Its Claims of Health Benefits?

    October 9, 2021

    Ministers Could be Forced to Make NHS Workforce Plans Public

    October 8, 2021

    Student Gives Prosthesis Project a Lightning-Themed Touch

    October 7, 2021
    Stay In Touch
    • Facebook
    • Twitter
    • Pinterest
    • Instagram
    • YouTube
    • Vimeo
    Our Picks

    COVID Antiviral Pills: What Scientists Still Want to Know

    October 9, 2021

    Does CBD Live Up to Its Claims of Health Benefits?

    October 9, 2021

    Ministers Could be Forced to Make NHS Workforce Plans Public

    October 8, 2021

    Student Gives Prosthesis Project a Lightning-Themed Touch

    October 7, 2021

    Subscribe to Updates

    Get the latest creative news from SmartMag about art & design.

    Demo
    About Us
    About Us

    Your source for the lifestyle news. This demo is crafted specifically to exhibit the use of the theme as a lifestyle site. Visit our main page for more demos.

    We're accepting new partnerships right now.

    Email Us: info@example.com
    Contact: +1-320-0123-451

    Our Picks

    Large Study of COVID Vaccine Side Effects in Sweden

    January 12, 2020

    Coronavirus latest: Japan’s Vaccination Rate Tops 75% As Cases Drop

    January 10, 2020
    8.9

    Review: Denmark Proposes Corona Pass Mandate for Workers

    January 9, 2020
    New Comments
    • turanaxyl on Pain, Burning after Ejaculation
    • m torress on Peyronie’s Disease Causes Pain, Psychological Trauma
    • WilliamPext on Ejaculation During Bowel Movement
    • Mesothelioma on Cancer: Causes, Types, Symptoms, and Treatment Guide
    Facebook X (Twitter) Instagram Pinterest
    • Home
    • Health
    • Covid19
    • News
    • Buy Now
    © 2025 ThemeSphere. Designed by ThemeSphere.

    Type above and press Enter to search. Press Esc to cancel.